Author

H. Newman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. E. Gaspar-Maia· 1 shared A. J. Lloyd· 1 shared A. Karsan· 1 shared A. Loewenstein· 1 shared A. Quintana· 1 shared A. Vedder· 1 shared A. Y. Ki· 1 shared B. D. Lacelles· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

A. E. Gaspar-Maia

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Author profile →

4 papers

Recent·Most cited

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

C. E. Rowland, H. Newman, T. T. Martin, R. Dods, N. Bournakas, J. M. Wagstaff, N. Lewis, S. J. Stanway, M. Balmforth, C. Kessler, K. van Rietschoten, D. Bellini, D. I. Roper, A. J. Lloyd, C. G. Dowson, , M. J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

Targeting BET Proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

C. Letson, M. E. Balasis, H. Newman, M. Binder, A. Vedder, F. Kinose, M. Ball, T. Kruer, A. Quintana, T. L. Lasho, C. M. Finke, L. L. Almada, J. M. Grants, G. Zhang, M. E. Fernandez-Zapico, , E. Padron

This study identifies PIM inhibitors as synergistic with BET inhibitors in myeloid leukemia, showing miR-33a downregulation drives PIM1 upregulation and GM-CSF hypersensitivity as a biomarker for combination therapy.

bioRxiv · Nov 1, 2022Cancer Biology

A multi-functional small molecule alleviates fracture pain and promotes bone healing

Y.-R. V. Shih, H. Newman, J. Hoque, B. D. Lacelles, S. Varghese

This study shows adenosine can reduce fracture pain and promote bone healing by targeting specific receptors in different cell types.

bioRxiv · May 27, 2022Bioengineering

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approach

M. Lisnyansky Barel, S. Y. Lee, A. Y. Ki, N. Kapelushnik, A. Loewenstein, K. Y. Chung, D. Schneidman-Duhovny, M. Giladi, H. Newman, Y. Haitin

The paper presents a structural model of full-length human DHDDS using computational and experimental methods, revealing a helix-loop-helix motif in the C-terminal domain and a DHDDS-NgBR heterodimer structure.

bioRxiv · Oct 7, 2019Biophysics