Inosine Induces Stemness Features in CAR T cells and Enhances Potency
D. D. Klysz, C. Fowler, M. Malipatlolla, L. Stuani, K. A. Freitas, S. Meier, B. Daniel, K. Sandor, P. Xu, J. Huang, L. Labanieh, A. Leruste, M. Bashti, V. Keerthi, J. Mata-Alcazar, , C. L. Mackall
This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.
bioRxiv · Apr 21, 2023Immunology