C. Fowler

Evolutionary and functional connections between the typhoid toxins encoded by S. Typhi and S. bongori

This study examines the evolutionary and functional links between typhoid toxins from S. Typhi and S. bongori, showing that S. Typhi's toxin is more potent in infecting human cells when derived from S. bongori.

Multi-omics characterization of highly enriched human plasma extracellular vesicles.

This study isolates and characterizes small extracellular vesicles from human plasma using multi-omics approaches, revealing novel protein and lipid profiles with potential biomarker value.

Conserved patterns of sequence diversification provide insight into the evolution of two-component systems in Enterobacteriaceae

The paper analyzes sequence divergence patterns of two-component systems (TCS) in Enterobacteriaceae to understand their evolutionary adaptation and identify atypical TCS with horizontally acquired alleles.

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants

The paper identifies the L452R mutation in the Spike protein as a key driver of recent SARS-CoV-2 variant expansion, particularly in California, and suggests its adaptive significance for viral infectivity and antibody escape.

Alternate subunit assembly diversifies the function of a bacterial toxin

This study shows that Salmonella Typhi produces two distinct typhoid toxin variants with different delivery components but shared active subunits, leading to functional versatility.