B. Daniel

Epigenomic programming of peripheral monocytes determines their transcriptional response to the tumor microenvironment

This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

Inosine Induces Stemness Features in CAR T cells and Enhances Potency

This study shows that inosine enhances CAR T cell stemness and function by modulating metabolism and epigenetics, leading to improved anti-tumor potency.

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

This study identifies the Mediator kinase module as a regulator of T cell differentiation and shows that its inhibition enhances effector T cell potency.

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

This study identifies distinct epigenetic trajectories in CD8+ T cells during acute infection, revealing how chromatin accessibility changes guide the development of tissue-resident memory T cells versus circulating memory T cells.

Divergent clonal differentiation trajectories of T cell exhaustion

This study identifies divergent clonal differentiation trajectories of T cell exhaustion during chronic viral infection, showing that TCR signal strength determines terminal or KLR Tex fates.

BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen

Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state

This study shows that macrophage inflammatory and regenerative responses are phase-dependent on the cell cycle, with S-G2/M phases linked to tissue remodeling and reduced IFNG-induced repolarization.

Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses

The paper identifies a subset of exhausted CD8 T cells with plasticity to reprogram into memory cells, suggesting new targets for immunotherapy.

Distribution and abundance of bottlenose dolphin (Tursiops truncatus) over the French Mediterranean continental shelf

The paper estimates the size of the bottlenose dolphin population in French Mediterranean waters using photo-identification and capture-recapture methods, finding 557 individuals.