Author

M. Blake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:behavioral assay· 1 Research Focus:differential expression· 1

Frequent Co-Authors

F. Kazmirczak· 2 shared K. Prins· 2 shared A. Cangelosi· 1 shared A. Pinto· 1 shared B. Kremer· 1 shared C. Berdasco· 1 shared C. C. Palsuledesai· 1 shared C. Guerrero· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

F. Kazmirczak

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ketone Bodies in Right Ventricular Failure: A Unique Therapeutic Opportunity

M. Blake, P. Puchalska, F. Kazmirczak, T. Thenappan, P. Crawford, K. Prins

This study investigates the effects of ketone bodies in right ventricular failure, showing improved RV function and reduced inflammation in a rat model.

bioRxiv · Apr 26, 2023Biochemistry

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

F. Kazmirczak, N. T. Vogel, S. Prisco, M. T. Patterson, J. Annis, R. T. Moon, L. M. Hartweck, J. B. Mendelson, M. Kim, N. Laixto Mancripe, T. Markowski, L. Higgins, C. Guerrero, B. Kremer, M. Blake, , K. Prins

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

bioRxiv · Jan 19, 2023 · PreprintBiochemistry

Cognitive deficits found in a pro-inflammatory state are independent of ERK 1/2 signaling in the murine brain hippocampus treated with Shiga toxin 2 from enterohemorrhagic Escherichia Coli

C. Berdasco, A. Pinto, M. Blake, F. Correa, N. A. Longo Carbajosa, P. A. Geogeghan, A. Cangelosi, M. M. Gironacci, J. Goldstein

This study shows that Stx2 induces cognitive deficits and inflammation in the hippocampus independently of ERK 1/2 signaling, while LPS requires ERK 1/2 for NF-kB activation.

bioRxiv · Aug 24, 2020 · PreprintPathology

Inhibition of the Myocardin-Related Transcription Factor pathway increases efficacy of Trametinib in NRAS-mutant melanoma cell lines

K. M. Appleton, C. C. Palsuledesai, S. A. Misek, M. Blake, J. Zagorski, T. S. Dexheimer, R. R. Neubig

This study shows that inhibiting the Rho/MRTF pathway with CCG-222740 enhances trametinib's effectiveness in NRAS-mutant melanoma cell lines by reducing cell viability and clonogenicity.

bioRxiv · Sep 19, 2019Cancer Biology