BiochemistrybioRxiv
FANCD2 and RAD51 recombinase directly inhibit DNA2 nucleases at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
W. Liu, P. Polaczek, I. Roubal…·J. L. Campbell
This study shows FANCD2 inhibits DNA2 nuclease activity and stabilizes RAD51 filaments to protect stalled replication forks, promoting genome stability.
DOI 10.1093/nar/gkad624