FANCD2 and RAD51 recombinase directly inhibit DNA2 nucleases at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
W. Liu, P. Polaczek, I. Roubal, Y. Meng, W.-c. Choe, M. C. Caron, C. A. Sedgeman, Y. Xi, C. Liu, Q. Wu, L. Zheng, J. Y. Masson, B. Shen, J. L. Campbell
This study shows FANCD2 inhibits DNA2 nuclease activity and stabilizes RAD51 filaments to protect stalled replication forks, promoting genome stability.
bioRxiv · Jul 8, 2021Biochemistry