MicrobiologybioRxiv
Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo
R. T. So, D. K. W. Chu, K. P. Y. Hui…·J. S. M. Peiris
This study identifies the nsp6 L232F mutation in MERS-CoV as enhancing viral replication in human respiratory tissues and mice, suggesting a role in human adaptation.