PhysiologybioRxiv
Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes
M. Flinn, S. Alvarez-Argote, M. C. Knas…·C. C. O'Meara
This study shows that Yap and Wwtr1 regulate Ccn3 in cardiac myofibroblasts, and their depletion reduces fibrosis and improves cardiac function after myocardial infarction.
DOI 10.3389/fcvm.2023.1142612