Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes
M. Flinn, S. Alvarez-Argote, M. C. Knas, V. Alencar, S. J. Paddock, X. Zhou, T. Buddell, A. Jamal, P. Liu, J. Drnevich, M. Patterson, B. Link, C. C. O'Meara
This study shows that Yap and Wwtr1 regulate Ccn3 in cardiac myofibroblasts, and their depletion reduces fibrosis and improves cardiac function after myocardial infarction.
bioRxiv · Dec 1, 2022Physiology