Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy
L. Muhandes, M. Pippel, M. Chapsa, R. Behrendt, Y. Ge, A. Dahl, B. Yi, A. Dalpke, S. Winkler, M. Hiller, S. Beissert, R. Jessberger, P. G. Fallon, A. Roers
This study shows that Flg-deficient mice do not develop spontaneous skin inflammation or atopy, but Flg deficiency may modulate dermatitis caused by other barrier defects.
bioRxiv · Sep 11, 2020 · PreprintImmunology