Author

M. Cigler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

G. E. Winter· 2 shared L. Depta· 2 shared L. Laraia· 2 shared A. Forrester· 1 shared A. Rukavina· 1 shared C. Kagiou· 1 shared C. Mayor-Ruiz· 1 shared C. Rossetti· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

G. E. Winter

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Author profile →

2 papers

Recent·Most cited

Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

N. He, L. Depta, C. Rossetti, M. Cigler, M. Michon, O. R. Dan, J. G. F. Hoock, J. Barbier, D. Gillet, A. Forrester, G. E. Winter, L. Laraia

This study identifies oxybipins, selective OSBP inhibitors, which block retrograde trafficking and reduce Shiga toxin toxicity by inducing Golgi degradation.

bioRxiv · Apr 1, 2023 · PreprintCell Biology

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology