Author

F. Frommelt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Fossati· 1 shared A. Rukavina· 1 shared C. Kagiou· 1 shared C. Mayor-Ruiz· 1 shared F. Uliana· 1 shared G. E. Winter· 1 shared G. Superti-Furga· 1 shared H. Imrichova· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. Fossati

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Author profile →

2 papers

Recent·Most cited

Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP

M. Cigler, H. Imrichova, F. Frommelt, L. Depta, A. Rukavina, C. Kagiou, J. T. Hannich, C. Mayor-Ruiz, G. Superti-Furga, S. Sievers, L. Laraia, H. Waldmann, G. E. Winter

This study identifies orpinolide as a compound that disrupts cholesterol transport in leukemia by targeting OSBP, revealing a therapeutic strategy for leukemic dependencies.

bioRxiv · Mar 15, 2023 · PreprintPharmacology & Toxicology

Mapping specificity, entropy, allosteric changes and substrates in blood proteases by a high-throughput protease screen

F. Uliana, M. Vizovisek, L. Acquasaliente, R. Ciuffa, A. Fossati, F. Frommelt, M. Gstaiger, V. De Filippis, U. auf dem Keller, R. Aebersold

The paper introduces a high-throughput proteomic method to profile protease activity and substrate specificity in native conditions, achieving high throughput and accuracy.

bioRxiv · Jul 20, 2020Biochemistry