Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations
K. Lake, M. Colonetta, C. Smith, K. Martinez-Algarin, K. Saunders, S. Mohta, J. Pena, H. L. McArthur, S. M. Reddy, E. T. Roussos-Torres, E. H. Chen, I. S. Chan
The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.
bioRxiv · Jan 29, 2023 · PreprintCancer Biology