Author

E. H. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1

Frequent Co-Authors

B. Ravaux· 2 shared J. H. Kim· 2 shared P. Pandey· 2 shared R. Zhang· 2 shared A. Frost· 1 shared B. Li· 1 shared C. Smith· 1 shared C. Thomas· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

B. Ravaux

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

Y. Lu, T. Walji, B. Ravaux, P. Pandey, B. Li, K. H. Lam, R. Zhang, D. J. Goldhamer, R. Li, D. W. Schmidtke, D. Pan, E. H. Chen

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

bioRxiv · Nov 27, 2023 · PreprintCell Biology

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

K. Lake, M. Colonetta, C. Smith, K. Martinez-Algarin, K. Saunders, S. Mohta, J. Pena, H. L. McArthur, S. M. Reddy, E. T. Roussos-Torres, E. H. Chen, I. S. Chan

The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.

bioRxiv · Jan 29, 2023 · PreprintCancer Biology

The mechanisms of dynamin-actin interaction

R. Zhang, N. Gerassimov, D. M. Lee, J. R. Jimah, S. Kim, D. Luvsanjav, J. Winkelman, M. Mettlen, M. E. Abrams, R. Kalia, P. Keene, P. Pandey, B. Ravaux, J. H. Kim, J. A. Ditlev, , E. H. Chen

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

bioRxiv · Mar 25, 2019 · PreprintCell Biology

Spectrin is a mechanoresponsive protein shaping the architecture of intercellular invasion

R. Duan, J. H. Kim, K. Shilagardi, E. Schiffhauer, S. Son, D. Lee, S. Li, C. Thomas, T. Luo, D. A. Fletcher, D. N. Robinson, E. H. Chen

The paper shows spectrin dynamically accumulates at fusogenic synapses in response to shear deformation, forming a sieve-like network that promotes cell membrane fusion during intercellular invasion.

bioRxiv · Jun 23, 2017Cell Biology