C. Smith

The STAT3-VDAC1 Axis Modulates Mitochondrial Function and Plays a Critical Role in the Survival of Acute Myeloid Leukemia Cells

Scoping Review of Maternal Monocytes and the Syncytiotrophoblast: Bi-Directional Communication in the Intervillous Space

This review examines maternal monocyte-trophoblast interactions in the intervillous space, identifying four categories of interaction and highlighting their roles in maternal disease.

AMHY and sex determination in egg-laying mammals

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling

This study uses computational models to show female atrial cardiomyocytes in AF have higher Ca2+-driven arrhythmia risk than males, with specific interventions identified to address these differences.

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

PI4KIII3β inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction

This study shows that inhibiting PI4KIIIβ reduces rhinovirus replication and ciliated cell loss in respiratory epithelial cultures from healthy and COPD patients.

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

Theoretical minimum uncertainty of modulation enhanced spinning disk confocal microscopy

This paper introduces SpinFlux, a modulation-enhanced spinning disk confocal microscopy method that improves localization precision over SMLM with minimal hardware modifications.

A multistage Plasmodium CRL4-WIG1 ubiquitin ligase is critical for the formation of functional microtubule organisation centres in microgametocytes

This study identifies a CRL4-related ubiquitin ligase in Plasmodium that is critical for microgametocyte formation by regulating proteostasis of ciliary and DNA replication proteins.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

A multiadjuvant polysaccharide-amino acid-lipid (PAL) subunit nanovaccine generates robust systemic and lung-specific mucosal immune responses against SARS-CoV-2 in mice

This study develops a mucosal nanovaccine that enhances both systemic and lung-specific immunity against SARS-CoV-2 in mice through intranasal and intramuscular delivery.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

The small mycobacterial ribosomal protein, bS22, modulates aminoglycoside accessibility to its 16S rRNA helix-44 binding site

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

Genome-wide mapping of the Escherichia coli PhoB regulon reveals many transcriptionally inert, intragenic binding sites

This study maps the PhoB regulon in E. coli and finds that most binding sites are intragenic and not associated with transcription regulation or conservation.

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.

High-resolution app data reveal sustained increases in recreational fishing effort in Europe during and after COVID-19 lockdowns

This study uses high-resolution app data to show increased recreational fishing effort in Europe during and after COVID-19 lockdowns, with effort remaining elevated by the end of 2021.

Does the Ice Age legacy end in Central Europe? The shrinking distributions of glacial relict crustaceans

This study assesses the status of glacial relict crustaceans in Lithuania and finds that two species are declining while one is likely extinct, with recommendations for conservation actions.

The Effect of Polymer Length in Phase Separation

This study investigates the thermodynamics of liquid-liquid phase separation in short polymer systems, showing that condensation depends on polymer length and concentration, with a negative free energy indicating stability.

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

Using pressure-driven flow systems to evaluate laser speckle contrast imaging

This study compares syringe pumps and pressure-regulated flow systems for microfluidic LSCI testing, finding pressure-regulated systems more reliable and MESI more accurate than LSCI.

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis

The paper investigates mutations in Plasmodium UBP-1 linked to drug resistance and shows how these mutations affect ubiquitin hydrolysis and parasite fitness.

An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle

This study identifies HCN ion channels as evolutionarily conserved pacemakers in smooth muscle, showing their role in peristalsis and pacemaker activity in the urinary tract.

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+-handling protein variation

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

The integrated LIM-peptidase domain of the CSA1/CHS3 paired immune receptor detects changes in DA1 family peptidase inhibitors to confer Albugo candida resistance in Arabidopsis.

The paper shows that the DAR4 ID in the CSA1/CHS3 receptor detects reduced DAR3 levels caused by Albugo candida, triggering defense mechanisms in Arabidopsis.

Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways

This study shows gene amplification helps a virus adapt to new species by overcoming antiviral defenses.

Cell environment shapes TDP-43 function: implications in neuronal and muscle disease

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

Modulation of Receptor-like Trans-Membrane Kinase 1 nuclear localisation by DA1 peptidases in Arabidopsis.

This study shows that DA1 peptidases cleave TMK1, releasing its kinase domain to the nucleus where it represses auxin-responsive cell growth during apical hook formation in Arabidopsis.

Association Mapping Across a Multitude of Traits Collected in Diverse Environments Identifies Pleiotropic Loci in Maize.

This study identifies pleiotropic loci in maize by analyzing trait associations across diverse environments using high-density genetic markers and resampling-based genome-wide association tests.