De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma
L. S. Elahi, M. Condro, R. Kawaguchi, Y. Qin, A. G. Alvarado, B. Gruender, H. Stewart, T. Li, A. Lai, M. Garrett, M. Castro, P. R. Lowenstein, H. Kornblum
This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.
bioRxiv · Nov 15, 2023Cancer Biology