A. Lai

Effect of Artificial Lung Fiber Bundle Geometric Design on Micro- and Macro-scale Clot Formation

This study examines how geometric parameters of artificial lung fiber bundles affect clot formation and proposes design changes to reduce thrombosis and improve efficiency.

Macrophages control pathological interferon responses during viral respiratory infection

This study identifies macrophage-derived Oncostatin M as a critical regulator of type I interferon responses during viral respiratory infection, preventing excessive inflammation.

A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function

This study identifies a novel non-canonical role for CSA in maintaining nuclear envelope integrity, linking DNA repair defects to progeroid phenotypes through NE dysfunction and immune activation.

De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma

This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.

Low- and high-grade glioma endothelial cells differentially regulate tumor growth

This study compares tumor endothelial cells from low-grade and high-grade gliomas, finding they have distinct molecular profiles and functional roles in regulating tumor growth.

Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization-An In Vivo Rat Model

The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2, Necroptosis, Pyroptosis and Panoptosis

This paper investigates how SARS-CoV-2 infection leads to the destruction of alveolar type II cells in fatal COVID-19 pneumonia through multiple inflammatory cell death pathways and suggests potential therapeutic strategies.

A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas

This paper develops a computational model of thrombosis that incorporates fibrin formation through contact activation of factor XII, validating it against experimental data from low-shear medical devices.

SARS-CoV-2 Omicron variant is more stable than the ancestral strain on various surfaces

This study compares the stability of the SARS-CoV-2 Omicron BA.1 variant with its ancestral strain on different surfaces, finding the Omicron variant more stable.

Highly basic clusters in the HSV-1 nuclear egress complex drive membrane budding by inducing lipid ordering

This study identifies how basic regions in the HSV-1 nuclear egress complex induce lipid ordering and negative curvature to drive membrane budding, with phosphorylation inhibiting this process.

Computational Simulations of the 4-D Micro-Circulatory Network in Zebrafish Tail Amputation and Regeneration

This study uses computational fluid dynamics to model microvascular changes in zebrafish tail regeneration, showing dynamic shifts in wall shear stress and flow rate during vascular remodeling.

Glioblastoma utilizes fatty acids and ketone bodies for growth allowing progression during ketogenic diet therapy

This study shows that glioblastoma uses fatty acids and ketone bodies for growth, and that ketogenic diet therapy does not effectively inhibit tumor progression.

Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

This study investigates sex-dependent effects of leptin receptor deficiency and Western diet on intervertebral disc pathology in a type 2 diabetes mouse model, finding altered disc morphology and bone quality in female mice.

μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cells

The paper introduces μDamID, a microfluidic platform that combines imaging and sequencing to study protein-DNA interactions in single cells, revealing 3D chromatin organization and gene regulation patterns.

On-ratio PDMS bonding for multilayer microfluidic device fabrication

The paper demonstrates that on-ratio PDMS bonding is effective for multilayer soft lithography, avoiding the issues of off-ratio bonding.