Cancer BiologybioRxiv
GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers
G. Bianco, M. Coto Llerena, J. Gallon…·S. Piscuoglio
This study identifies GATA3 and MDM2 as synthetic lethal in ER-positive breast cancers, showing MDM2 inhibition can target GATA3-deficient tumors via the PI3K/Akt/mTOR pathway.
DOI 10.1038/s42003-022-03296-x