Author

M. Cotten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:virus· 2 Organism:bacteria (other)· 1 Organism:chicken / avian· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

M. V. T. Phan· 2 shared A. B. Messink· 1 shared A. I. Greenwood· 1 shared A. Rice· 1 shared B. Lubinski· 1 shared D. Bugumbe· 1 shared D. Heederik· 1 shared D. L. Robertson· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersEvolutionary Biology

M. V. T. Phan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evolution to increased positive charge on the viral spike protein may be part of the adaptation of SARS-CoV-2 to human transmission

M. Cotten, M. V. T. Phan

The paper examines changes in the charge of the SARS-CoV-2 spike protein over time and suggests these changes may aid viral transmission and infection.

bioRxiv · Jul 30, 2022 · PreprintEvolutionary Biology

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda

B. Lubinski, L. Frazier, M. Phan, D. Bugumbe, J. L. Cunningham, T. Tang, S. Daniel, M. Cotten, J. A. Jaimes, G. Whittaker

The paper analyzes the P681R mutation in the SARS-CoV-2 spike protein of variant A.23.1, showing increased furin cleavage and infectivity compared to earlier variants, but only when combined with other spike changes.

bioRxiv · Jun 30, 2021 · PreprintMicrobiology

Unique protein features of SARS-CoV-2 relative to other Sarbecoviruses

M. Cotten, D. L. Robertson, M. V. T. Phan

The paper identifies unique protein features of SARS-CoV-2 compared to other Sarbecoviruses, highlighting regions that may support human infection and transmission.

bioRxiv · Apr 6, 2021Evolutionary Biology

Establishing farm dust as a useful viral metagenomic surveillance matrix

K. T. T. Kwok, M. M. T. de Rooij, A. B. Messink, I. Wouters, L. A. M. Smit, M. Cotten, D. Heederik, M. Koopmans, M. V. Phan

This study characterizes viral communities in chicken farm dust and feces, showing dust can be used for viral metagenomic surveillance.

bioRxiv · Mar 9, 2021Evolutionary Biology

Lipopolysaccharide Simulations are Sensitive to Phosphate Charge and Ion Parameterization

A. Rice, M. T. Rooney, A. I. Greenwood, M. Cotten, J. Weresczczynski

This study shows that LPS simulations are sensitive to phosphate charge and ion parameterization, with protonated LPS and specific cations providing better agreement with experiments.

bioRxiv · Jan 22, 2020Biophysics