A. Rice

Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

This study shows that changes in the extracellular matrix in IPF affect KRT5+ basal cell migration and function, contributing to lung fibrosis.

Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

This study links gut bacteria-derived sphingolipids to enhanced innate immune responses to an oral cholera vaccine using metagenomic and experimental approaches.

Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration.

This study shows that influenza viral fusion peptides aggregate on membranes, altering structure and hydration to promote poration.

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

Complete Protection of Nasal and Lung Airways Against SARS-CoV-2 Challenge by Antibody Plus Th1 Dominant N- and S-Specific T-Cell Responses to Subcutaneous Prime and Thermally-Stable Oral Boost Bivalent hAd5 Vaccination in an NHP Study

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

Model Adequacy Tests for Likelihood Models of Chromosome-Number Evolution

The paper introduces a model adequacy test for likelihood models of chromosome-number evolution and demonstrates its application to angiosperm genera, finding poor model fit in many cases.

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

Lipopolysaccharide Simulations are Sensitive to Phosphate Charge and Ion Parameterization

This study shows that LPS simulations are sensitive to phosphate charge and ion parameterization, with protonated LPS and specific cations providing better agreement with experiments.

Automation of citation screening in pre-clinical systematic reviews

The paper develops machine learning classifiers to automate citation screening in pre-clinical systematic reviews, achieving high sensitivity and specificity across different domains.