A. Berger

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

First concrete documentation for presence of Aedes (Stegomyia) albopictus in Bolivia: Dispelling previous anecdotes

This study confirms the presence of Aedes albopictus in Bolivia through larval sampling and morphological identification, marking the first concrete documentation of the species in the country.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

This study shows that USP9X stabilizes RIT1 protein and that its depletion reduces RIT1 abundance and sensitizes cells to EGFR inhibitors.

Geographic variation in the songs of two closely related song-learning species, Anna's and Costa's hummingbird (Calypte anna, C. costae)

This study examines geographic variation in songs of two hummingbird species, finding that Anna's hummingbirds show population-level song variation while Costa's hummingbirds show minor frequency differences.

Functional expression of a Mo-dependent formate dehydrogenase in Escherichia coli under aerobic conditions

The paper reports the functional expression of a Mo-dependent formate dehydrogenase in E. coli under aerobic conditions, showing growth on formate as sole energy source and identifying mutations in a formate transporter gene as key to adaptation.

Sterol 3-beta-Glucosyltransferase TRANSPARENT TESTA15 Controls Seed Development and Flavanol Accumulation through its Role in Vacuole Biogenesis and Maintenance in Arabidopsis

This study shows that TT15 controls seed development and flavanol accumulation by modulating vacuole biogenesis and maintenance in Arabidopsis.

Diversity loss in microbial ecosystems undergoing gradual environmental changes

This study models how gradual environmental changes impact microbial ecosystems, showing that diversity loss leads to slowed dynamics and potential response lags in diverse ecosystems.

No Wolbachia protection against Plasmodium falciparum infection in the major malaria mosquito Anopheles moucheti

This study investigates whether Wolbachia infection in Anopheles moucheti mosquitoes affects Plasmodium falciparum infection, finding no correlation between Wolbachia density and parasite development.

Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance

The paper shows that glutamine synthetase mRNA produces an sRNA, GlnZ, which regulates carbon/nitrogen metabolism by repressing SucA expression.

Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

This study identifies oncogenic KRAS-induced splicing factor phosphorylation and alternative splicing events in lung cancer cells.

Cell Painting predicts impact of lung cancer variants

The paper uses Cell Painting to predict the functional impact of lung cancer variants by analyzing cell morphology at the single-cell level.

AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in Castrate-Resistant Prostate Cancer

This study identifies unique nuclear import and chromatin engagement mechanisms of AR-V7 in castrate-resistant prostate cancer, suggesting a Hit-and-Run transcriptional mode.

Emergence of NADP+-reducing enzymes in Escherichia coli central metabolism via adaptive evolution

This study shows that adaptive evolution in E. coli can change cofactor specificity of enzymes, enabling NADPH regeneration without external sources, but is limited by thermodynamic constraints.

The road to sorghum domestication: evidence from nucleotide diversity and gene expression patterns

This study analyzes gene expression and nucleotide diversity in domesticated and wild sorghum to identify genetic changes associated with domestication.

Sort-purification of human CD34+CD90+ cells reduces target cell population and improves lentiviral transduction

This study compares CD34+CD90+ cell purification to other HSC-enrichment strategies, showing it reduces target cells but improves lentiviral transduction and engraftment.

Toxigenic and zoonotic Corynebacterium ulcerans emerges from widespread hedgehog disease

The paper isolates toxin-producing Corynebacterium ulcerans from diseased hedgehogs in Belgium, highlighting strain diversity and low antimicrobial resistance.

Optimized qRT-PCR approach for the detection of intra- and extracellular SARS-CoV-2 RNAs

This study presents an optimized qRT-PCR method for detecting SARS-CoV-2 RNA using a low-cost SYBR green approach, showing improved detection limits and simplicity compared to multi-step assays.

Mapping the unique and shared functions of oncogenic KRAS and RIT1 with proteome and transcriptome profiling

This study compares proteomic and transcriptomic profiles of KRAS and RIT1 mutant lung cells to identify shared and divergent functions in oncogenic signaling.

From Farm to Pharmacy: Strawberry-Enabled Oral Delivery of Protein Drugs

This study identifies strawberry-derived pelargonidin as a safe and effective permeability enhancer for oral delivery of protein drugs in mice.

Machine learning goes wild: Using data from captive individuals to infer wildlife behaviour

This paper trains machine learning models on captive fox data to infer wild fox behavior without direct observation, finding that ANN with moving windows outperformed traditional methods.

Modularity and evolution of flower shape: the role of efficiency, development, and spandrels in Erica

This study investigates floral modularity in Erica species, showing that generalist flowers depend on development while specialists are linked to efficiency, with shape PC1 adapting to novel pollinators.

Evolutionary forces affecting synonymous variations in plant genomes

The paper investigates the evolutionary forces shaping synonymous variations in plant genomes, finding that GC-biased gene conversion is more prevalent and stronger than selection in most species.