Immune cells lacking Y chromosome have widespread dysregulation of autosomal genes
J. P. Dumanski, J. Halvardson, H. Davies, E. Rychlicka-Buniowska, J. Mattisson, B. Torabi Moghadam, N. Nagy, K. Weglarczyk, K. Bukowska-Strakova, M. Danielsson, P. Olszewski, A. Piotrowski, E. Oerton, A. Ambicka, M. Przewoznik, , L. A. Forsberg
The paper examines immune cells with mosaic loss of the Y chromosome, finding widespread dysregulation of autosomal genes and linking this to immune dysfunction and disease.
bioRxiv · Feb 16, 2020Immunology