N. Dahl

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

Advancing Cell Therapies: Single-Cell Profiling, Generation, Expansion, and Gene Delivery in Rhesus Macaque Plasma B Cells

This study expands NHP B cells ex vivo, identifies unique plasma cell markers, and establishes AAV transduction conditions for engineered B cell therapies.

Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications

This study investigates epigenetic changes in GABAergic development using DS iPSCs and shows that VPA can rescue some chromatin abnormalities.

Efficient methods for generation and expansion of, and gene delivery to Rhesus Macaque plasma B cells

The paper develops methods to expand and transduce rhesus macaque B cells for potential cell therapy applications.

Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in Myc-driven Medulloblastoma

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

Combined mRNA and protein single cell analysis in a dynamic cellular system using SPARC

This study introduces SPARC, a method to co-profile mRNA and protein in single cells, showing they provide complementary information about cellular states.