BiochemistrybioRxivPreprint
Small Molecule Disruption of a Protein Disulfide Isomerase-Containing Multi-Protein Complex Causes Broad Cancer Selective Metabolic Collapse and Tumor Inhibition in vivo
Anuradha F. Lingappa, Suguna Mallesh, Maya Michon…·Stevan Pecic
PAV-620 and PAV-805 disrupt PDI-containing complexes, causing metabolic collapse and tumor inhibition in cancer models without toxicity to healthy cells.