M. Dogan

Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy

This study develops a synthetic biology toolbox to engineer CAR-T cells with tunable controls, enabling safe and effective cancer immunotherapy through fail-safe mechanisms.

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells

This paper develops a 3D bioprinted vascularized breast tumor model to dynamically screen chemotherapeutics and CAR-T cells, showing dose-dependent drug response and significant tumor reduction with CAR-T treatment.

Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors

This study develops 3D breast cancer models with engineered MAIT cell receptors to assess their cytotoxic activity against tumor cells.

Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

This paper develops a bispecific T cell engager (ACE2-Bite) that targets SARS-CoV-2 infected cells and neutralizes variants, showing higher affinity for Delta and Omicron.