D. Unutmaz

Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy

This study develops a synthetic biology toolbox to engineer CAR-T cells with tunable controls, enabling safe and effective cancer immunotherapy through fail-safe mechanisms.

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells

This paper develops a 3D bioprinted vascularized breast tumor model to dynamically screen chemotherapeutics and CAR-T cells, showing dose-dependent drug response and significant tumor reduction with CAR-T treatment.

Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

This study shows that 2DG inhibits glycolysis in human T cells, increasing IL-17-producing subsets like Th17 and MAIT cells, with effects reversed by mannose.

Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors

This study develops 3D breast cancer models with engineered MAIT cell receptors to assess their cytotoxic activity against tumor cells.

Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

This paper develops a bispecific T cell engager (ACE2-Bite) that targets SARS-CoV-2 infected cells and neutralizes variants, showing higher affinity for Delta and Omicron.

Multi-omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

This study uses multi-omics analyses to compare short- and long-term ME/CFS patients with healthy controls, identifying microbiome and metabolic differences and potential biomarkers.

Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

This study identifies altered T cell subset frequencies and functions in ME/CFS patients, suggesting chronic immune activation and potential biomarkers.

Live cell kinetic analysis of the LMO2/LDB1 leukemogenic protein complex reveals a hierarchy of turnover with implications for complex assembly

The paper analyzes the kinetic stability of the LMO2/LDB1 complex subunits and identifies LDB1 as a stabilizer and nucleator of the complex.