Author

E. Karhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Unutmaz· 5 shared L. Kozhaya· 5 shared L. Placek· 4 shared M. Dogan· 3 shared M. Yigit· 2 shared X. Chen· 2 shared C. Gunter· 1 shared C. Mohammed· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersImmunology

D. Unutmaz

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5 papers

Recent·Most cited

Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy

M. Dogan, L. Kozhaya, L. Placek, E. Karhan, M. Yigit, C. Mohammed, Q. Zhao, D. Unutmaz

This study develops a synthetic biology toolbox to engineer CAR-T cells with tunable controls, enabling safe and effective cancer immunotherapy through fail-safe mechanisms.

bioRxiv · Jul 9, 2024 · PreprintImmunology

Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy

M. Dogan, E. Karhan, L. Kozhaya, L. Placek, X. Chen, M. Yigit, D. Unutmaz

This paper engineers MAIT cells with CARs to target cancer cells, showing comparable cytotoxicity to CD8+ CAR-T cells but with lower IFN-γ expression.

bioRxiv · Jul 28, 2022 · PreprintImmunology

Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

X. Chen, L. Kozhaya, C. Wang, L. Placek, E. Karhan, D. Unutmaz

This study shows that 2DG inhibits glycolysis in human T cells, increasing IL-17-producing subsets like Th17 and MAIT cells, with effects reversed by mannose.

bioRxiv · Mar 13, 2022 · PreprintImmunology

Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors

M. Dey, M. H. Kim, M. Nagamine, E. Karhan, L. Kozhaya, M. Dogan, D. Unutmaz, I. T. Ozbolat

This study develops 3D breast cancer models with engineered MAIT cell receptors to assess their cytotoxic activity against tumor cells.

bioRxiv · Jan 29, 2022 · PreprintImmunology

Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

E. Karhan, C. Gunter, V. Ravanmehr, M. Horne, L. Kozhaya, S. Renzullo, L. Placek, J. George, P. N. Robinson, S. D. Vernon, L. Bateman, D. Unutmaz

This study identifies altered T cell subset frequencies and functions in ME/CFS patients, suggesting chronic immune activation and potential biomarkers.

bioRxiv · Dec 23, 2019 · PreprintImmunology