Cell BiologybioRxiv
Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.
C. Ramos-Perez, M. Dominska, L. Anaissi-Afonso…·F. Machin
The paper investigates the effects of Top2 deficiency-induced mitotic catastrophe in budding yeast, finding that 75% of daughter cells become senescent and later decline in vitality with genomic imbalances.
DOI 10.18632/aging.102573