Cell BiologybioRxiv
Liver Receptor Homolog-1 (LRH-1/NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
R. Lambrecht, M. E. Delgado, V. Gloe…·T. Brunner
This study shows that LRH-1 deletion protects mice from TNF-induced liver damage by inhibiting NF-B activity and promoting BIM degradation.
DOI 10.1016/j.celrep.2023.113513