MicrobiologyProceedings of the National Academy of SciencesPeer-reviewed
Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection
Patryk A. Krakowiak, M. E. Flores, Sean R. Cuddy…·Anna Ruth Cliffe
This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.
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