Author

Sean R. Cuddy

University of VirginiaORCID 0000-0002-2062-0691Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

Abigail L. Whitford· 2 shared Anna Ruth CliffeiD· 2 shared Patryk A. KrakowiakiD· 2 shared Sara Anna DochnaliD· 2 shared Aleksandra W. BabnisiD· 1 shared Alison K. FrancoisiD· 1 shared Daniel A. Engel· 1 shared M. E. FloresiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMicrobiology

Abigail L. Whitford

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2 papers

Recent·Most cited

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedJan 24, 2025

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection

Patryk A. Krakowiak, M. E. Flores, Sean R. Cuddy…·Anna Ruth Cliffe

This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.

9 citationstop 3%

humanexperimental assay

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MicrobiologyJournal of VirologyPeer-reviewedJan 9, 2024

c-Jun Signaling During Initial HSV-1 Infection Modulates Latency to Enhance Later Reactivation in addition to Directly Promoting the Progression to Full Reactivation

Sara Anna Dochnal, Abigail L. Whitford, Alison K. Francois…·Anna Ruth Cliffe

This study shows c-Jun signaling during HSV-1 initial infection promotes latency and enhances later reactivation by facilitating the transition from Phase I to Phase II reactivation.

19 citationstop 3%

humanexperimental assay

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