Cell BiologybioRxiv
NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation
A. v. Sharrock, T. S. Mulligan, K. R. Hall…·J. S. Mumm
This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.
DOI 10.1038/s41592-021-01364-4