Author

A. D. Lander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. K. Ganesan· 2 shared C.-F. Chen· 2 shared J. Shiu· 2 shared M. G. Caldwell· 2 shared R. Ruiz-Vega· 2 shared A. Calof· 1 shared A. v. Sharrock· 1 shared D. Ding· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. K. Ganesan

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4 papers

Recent·Most cited

The inherent fragility of collective proliferative control

M. G. Caldwell, A. D. Lander

This paper shows that stochastic effects can cause rare but catastrophic failures in renewal control, potentially contributing to cancer development and recurrence.

bioRxiv · Jan 23, 2024Cancer Biology

Uncovering Minimal Pathways in Melanoma Initiation

H. Xiao, J. Shiu, C.-F. Chen, J. Wu, P. Zhou, S. S. Telang, R. Ruiz-Vega, A. D. Lander, A. K. Ganesan

This study identifies LNM cells as a pre-malignant state in melanoma initiation, showing they pre-exist in normal skin, expand with Braf activation, and contribute to drug resistance.

bioRxiv · Dec 8, 2023Cancer Biology

Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

R. Ruiz-Vega, C.-F. Chen, E. Razzak, P. Vasudeva, T. Krasieva, J. Shiu, M. G. Caldwell, H. Yan, J. Lowengrub, A. K. Ganesan, A. D. Lander

The paper investigates nevus growth arrest using a mouse model and finds that collective cell behavior, not cell-autonomous senescence, explains nevus size control.

bioRxiv · Jul 14, 2020Cancer Biology

NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

A. v. Sharrock, T. S. Mulligan, K. R. Hall, E. M. Williams, D. T. White, L. Zhang, F. Matthews, S. Nimmagadda, S. Washington, K. Le, D. Meir-Levi, O. L. Cox, M. T. Saxena, A. Calof, M. E. Lopez-Burks, , J. S. Mumm

This paper describes the development of NTR 2.0, a modified nitroreductase with significantly improved efficacy for targeted cell ablation using metronidazole.

bioRxiv · May 22, 2020Cell Biology