The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2
S. Chaib, J. A. Lopez-Dominguez, M. Lalinde…·M. Serrano
This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.