M. Serrano

Ultrasound-based prediction of spawning time in females of Octopus vulgaris

This study uses ultrasound to predict spawning time in cultured and wild Octopus vulgaris by analyzing ovary volume and gonadosomatic index.

The impact of YabG mutations on C. difficile spore germination and processing of spore substrates

This study investigates how mutations in YabG affect C. difficile spore germination and substrate processing, showing altered substrate cleavage and expression patterns.

Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profile

This study identifies H4K20me3 heterochromatin in persister cancer cells, which reduces their inflammatory profile and reveals vulnerabilities in one-carbon metabolism.

A targeted metabolomic method to detect epigenetically relevant metabolites

The paper introduces a targeted metabolomic method to detect epigenetically relevant metabolites using biphasic extraction and stable isotope tracing.

A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity

The paper identifies a TFEB-TGFβ signaling axis that regulates diapause and stem cell longevity across species by coordinating nutrient availability with growth signals.

A new fluorescence-based approach for direct visualization of coat formation during sporulation in Bacillus cereus

This paper uses fluorescence microscopy to visualize coat formation during sporulation in B. cereus and identifies a subpopulation of engulfment-defective cells.

Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth

The paper analyzes vaginal microbiome metagenomic data to identify genetic diversity and antimicrobial resistance gene associations with preterm birth.

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

Induction of senescence renders cancer cells highly immunogenic

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

This study shows that a single cycle of transient OSKM expression reverses aging-related DNA methylation, transcriptional, and metabolic changes in multiple tissues of aged mice.

The morphogenetic protein CotE drives exosporium formation by positioning CotY and ExsY during sporulation of Bacillus cereus

This paper uses super-resolution fluorescence microscopy to show that CotE positions CotY and ExsY during exosporium formation in B. cereus, revealing a two-cap assembly mechanism.

Apoptosis, G1 phase stall and premature differentiation account for low chimeric competence of Human and rhesus monkey naive pluripotent stem cells

Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation

This study shows that activation of the p53/p21 pathway limits acute lung injury by reducing cell apoptosis but also induces early senescence in alveolar cells.

A regulatory protein that represses sporulation in Clostridioides difficile

This study identifies csiA as a regulator that suppresses sporulation in C. difficile by reducing spo0A expression, affecting sporulation initiation without altering toxin or motility gene expression.

Long reads from Nanopore sequencing as a tool for animal microbiome studies

This study compares Illumina and Oxford Nanopore sequencing for ruminal microbiome analysis, finding that ONT provides more species-level classification due to longer reads but struggles with low-abundance archaeal and eukaryotic species.

A novel microRNA-based strategy to expand the differentiation potency of stem cells

This study shows that transient exposure to miR-203 enhances the differentiation capacity of murine and human PSCs by reversing DNA methylation.

From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile

This study traces the evolutionary origin and specialization of sporulation in Bacillus subtilis and Clostridioides difficile, identifying key gene gain events and horizontal gene transfer patterns.

Structure and assembly of a Clostridioides difficile spore polar appendage

This study investigates the structure and role of the polar appendage in Clostridioides difficile spores, showing its impact on germination and virulence.

A protein phosphorylation module patterns the Bacillus subtilis spore outer coat

This study identifies a protein phosphorylation module involving CotB, CotG, and CotH that establishes the structural pattern of the Bacillus subtilis spore outer coat.