Author

J. A. Lopez-Dominguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Marin· 2 shared M. Serrano· 2 shared N. Prats· 2 shared A. Caballe· 1 shared A. Canella· 1 shared A. Garcia-Garijo· 1 shared A. Gros· 1 shared A. J. Covarrubias· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

I. Marin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 4, 2022

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde…·M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

DOI 10.1101/2022.11.04.501681

humanmouse

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 5, 2022

Induction of senescence renders cancer cells highly immunogenic

I. Marin, O. Boix, A. Garcia-Garijo…·M. Serrano

This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.

DOI 10.1101/2022.06.05.494912

mousehuman

𝕏 PostBluesky

PhysiologybioRxivPreprintFeb 22, 2022

Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

M. Stratton, J. A. Lopez-Dominguez, A. Canella…·G. A. Cortopassi

This study finds that a long-term ketogenic diet increases SOX2-dependent oligodendrocyte and myelination gene expression in aged mouse brains.

DOI 10.1101/2022.02.22.481437

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivJul 31, 2019

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone…·E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

DOI 10.1038/s42255-020-00305-3

mousebulk RNA-seq

𝕏 PostBluesky