Author

S. Chaib

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Meyer· 2 shared M. Aguilera· 2 shared M. Serrano· 2 shared N. Prats· 2 shared A. Agusti· 1 shared A. Blees· 1 shared A. E. Roehrigh· 1 shared A. Hergovich· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

K. Meyer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde, N. Prats, I. Marin, K. Meyer, M. I. Munoz, M. Aguilera, L. Mateo, C. S.-O. Attolini, S. Llanos, M. Escorihuela, S. Perez-Ramos, F. Al-Shahrour, T. P. Cash, , M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

bioRxiv · Nov 4, 2022 · PreprintCancer Biology

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

M. Maus, V. Lopez-Polo, M. Lafarga, M. Aguilera, E. De Lama, K. Meyer, A. Manonelles, A. Sola, C. Lopez Martinez, I. Lopez-Alonso, F. Hernandez-Gonzales, S. Chaib, M. Rovira, M. Sanchez, R. Faner, , M. Serrano

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

bioRxiv · Jul 29, 2022Physiology

Role for Merlin/NF2 in transcription elongation through interaction with the PAF complex

A. E. Roehrigh, K. Klupsch, J. A. Oses-Prieto, S. Chaib, S. Henderson, W. Emmett, L. C. Young, S. Surinova, A. Blees, A. Pfeiffer, M. Tijani, F. Brunk, N. Hartig, M. Munoz-Alegre, A. Hergovich, , P. Rodriguez-Viciana

This study shows Merlin interacts with the PAF complex to regulate transcription elongation, linking cell-cell adhesion to tumor suppression.

bioRxiv · Jul 28, 2019 · PreprintCancer Biology