KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma
E. Figuerola-Bou, C. Rios-Astorch, E. Blanco, M. Sanchez-Jimenez, P. Taboas, G. Fernandez, S. Gomez, O. Munoz, P. Castellano-Escuder, S. Perez-Jaume, E. Prada, S. Mateo-Lozano, N. Riggi, A. Avgustinova, C. Lavarino, , J. Mora
This study identifies KDM6A and KDM6B as EWSR1-FLI1 cofactors in Ewing Sarcoma, showing distinct roles in enhancer activation and tumor growth.
bioRxiv · Jan 24, 2023Cancer Biology