The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin.
C. Stok, N. van den Tempel, M. Everts, E. Wierenga, F. Bakker, Y. Kok, I. Teles Alves, L. Jae, A. Bhattacharya, E. Karanika, P. Perepelkina, S. Bergink, K.-L. Chan, R. de Boer, R. Fehrmann, M. van Vugt
The paper identifies C1orf112 as a synthetic lethal partner of PICH, showing it stabilizes FIGNL1 and regulates RAD51 retention on chromatin, impacting genome maintenance.
bioRxiv · Oct 7, 2022 · PreprintCancer Biology