The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection
M. Martins, M. Nooruzzaman, J. L. Cunningham…·D. G. Diel
This study shows the Omicron BA.1 Spike protein reduces SARS-CoV-2 virulence in a feline model by impairing viral spread and causing less severe disease.