Author

P. Knipscheer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:Xenopus· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

K. Sato· 3 shared M. Altelaar· 2 shared A. Audrey· 1 shared A. G. M. Hendrikx· 1 shared A. J. R. Heck· 1 shared A. M. Heijink· 1 shared A. N. Zelensky· 1 shared A. Ray Chaudhuri· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

K. Sato

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

R. Ghouil, S. Miron, K. Sato, D. Ristic, S. E. van Rossum-Fikkert, P. Legrand, M. Ouldali, J.-M. Winter, V. Ropars, G. David, A.-A. Arteni, C. Wyman, P. Knipscheer, R. Kanaar, A. N. Zelensky, S. Zinn-Justin

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

bioRxiv · Apr 27, 2023Biochemistry

RNA transcripts suppress G-quadruplex structures through G-loop formation

K. Sato, A. G. M. Hendrikx, P. Knipscheer

The paper shows G-loop structures suppress mutagenic G4s by promoting RNA transcript hybridization and DNA synthesis, preventing genomic instability.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

A. M. Heijink, C. Stok, D. Porubsky, E. M. Manolika, Y. P. Kok, M. Everts, H. R. de Boer, A. Audrey, E. Wierenga, V. Guryev, D. C. J. Spierings, P. Knipscheer, A. Ray Chaudhuri, P. M. Lansdorp, M. A. T. M. van Vugt

This study shows PARP inhibitors induce sister chromatid exchanges (SCEs) through under-replicated DNA processed in mitosis, independent of homologous recombination factors.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics

J. M. Valverde, G. Dubra, H. van den Toorn, G. van Mierlo, M. Vermeulen, A. J. R. Heck, P. Knipscheer, L. Krasinska, D. Fisher, M. Altelaar

The paper uses single-embryo phosphoproteomics to show that phosphorylation of intrinsically disordered proteins by cell cycle kinases drives switch-like mitotic reorganization.

bioRxiv · Aug 29, 2021 · PreprintCell Biology

Multistep mechanism of DNA replication-coupled G-quadruplex resolution

K. Sato, N. Martin-Pintado, H. Post, M. Altelaar, P. Knipscheer

The paper identifies a three-step mechanism for resolving G-quadruplex structures during DNA replication using Xenopus egg extracts.

bioRxiv · Nov 11, 2020 · PreprintBiochemistry