Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature
C. J. Childs, H. M. Poling, K. Chen, Y.-H. Tsai, A. Wu, C. W. Sweet, A. Vallie, M. K. Eiken, S. Huang, R. Schreiner, Z. Xiao, A. S. Conchola, M. F. Anderman, E. M. Holloway, A. Singh, , J. R. Spence
This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.
bioRxiv · Nov 6, 2023 · PreprintBioengineering