A. Wu

Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients.

The paper shows reduced ZMPSTE24 leads to prelamin accumulation and steatosis in MASLD patients, linking it to p53 activation and metabolic dysfunction.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Biomarker Identification by Proteomic Analysis of Vitreous Humor and Plasma in Diabetic Retinopathy

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon

This study shows that Smad4 loss in the mouse intestinal epithelium reduces pathological fibrosis and improves mucosal repair after DSS-induced injury.

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR

The paper shows Foxa2 enables chromatin conformation changes during FXR ligand activation in mouse livers, increasing long-range interactions and altering TADs and loops.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

Grapevine scion gene expression is driven by rootstock and environment interaction

The paper investigates how rootstock genotype affects scion gene expression in grapevines under field conditions, finding that this influence is tissue- and time-dependent and interacts with environmental factors.

Exploring the genome and protein space of viruses

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

A cross-scale analysis to understand and quantify effects of photosynthetic enhancement on crop growth and yield

The paper uses a cross-scale model to predict how photosynthetic manipulations affect wheat and sorghum yield across environments, finding modest gains with some strategies and challenges in scaling up.

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

Genomic evidence for divergent co-infections of SARS-CoV-2 lineages

This study identifies co-infection events of SARS-CoV-2 lineages in genomic data, finding 53 events across 29,993 samples, including one triple lineage infection, and notes an increasing trend with viral diversity.

Semi-supervised sequence modeling for improved behavioral segmentation

This paper introduces a semi-supervised sequence model for behavioral segmentation that combines supervised, weakly supervised, and self-supervised losses to improve accuracy with sparse labels.

In vitro models of the human esophagus reveal ancestrally diverse response to injury

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

Protein detection in blood with single-molecule imaging

This paper introduces SMAC, a single-molecule imaging technique that detects disease-specific proteins in blood samples at subfemtomolar concentrations.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battle

The paper screens drugs to block fibrogenic differentiation in Duchenne Muscular Dystrophy mice, but finds no significant improvement in muscle histopathology despite in vitro hits.

Controlling T cells shape, mechanics and activation by micropatterning.

This paper demonstrates a method to control T cell shape, mechanics, and activation using micropatterned substrates and shows that adhesion to aCD45 does not affect calcium fluxes.

Deep Graph Pose: a semi-supervised deep graphical model for improved animal pose tracking

This paper introduces a semi-supervised deep graphical model for animal pose tracking that improves accuracy by leveraging spatial and temporal constraints in behavioral videos.

Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

From phages to mammalian viruses: viral receptors play a central role in protein-protein interaction network

The paper curates a database of phage-host receptor interactions and finds that viral receptors, both in phages and mammalian viruses, are central in host protein-protein interaction networks.

Self-assembled primary tumor clusters for precision cancer therapy

This paper introduces a novel patient-derived tumor-like cell cluster model for personalized drug testing, showing high similarity to original tumors and enabling rapid drug testing within 10-20 days.

Serum Alpha-2-Macroglobulin as an intrinsic radioprotective factor in patients undergoing thoracic radiation therapy

This study investigates the association between baseline alpha-2-macroglobulin levels and radiation-induced toxicities in thoracic radiotherapy patients, finding a link with esophagitis and developing predictive models for toxicity.