C. Loebel

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels

This study develops a Matrigel-free method using synthetic hydrogels to form alveolar organoids, showing they secrete their own extracellular matrix for growth.

Quantification of local matrix deposition during muscle stem cell activation using engineered hydrogels

This study quantifies matrix deposition by muscle stem cells during activation using engineered hydrogels and shows it is critical for maintaining stem cell function.

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma 3D organoids and identify matrix-activated therapeutic targets

The paper develops a hydrogel platform to study matrix mechanics in EAC organoids and identifies therapeutic targets for ECM stiffness.

Microstructured hydrogels to guide self-assembly and function of lung alveolospheres

This paper introduces a hydrogel-based method to culture lung alveolospheres without Matrigel, reducing heterogeneity while maintaining cell fate.

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.