Cell confinement reveals a branched-actin independent circuit for neutrophil polarity
B. R. Graziano, J. P. Town, T. L. Nagy, M. Fosnaric, S. Penic, A. Iglic, V. Kralj-Iglic, N. Gov, A. Diz-Munoz, O. D. Weiner
This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.
PLOS Biology · Oct 10, 2019Peer-reviewedCell Biology