N. Gov

Trade-off between branching and polarity controls decision-making during cell migration

The paper develops a theoretical model and experimental analysis to study how branched cells balance shape dynamics for directional decision-making during migration.

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

This paper develops a minimal physical model to explain curvotaxis by simulating curved protein complexes at the cell's leading edge and shows it matches experimental observations on curved substrates.

How motility drives the glassy dynamics in confluent epithelial monolayers?

This paper develops a theoretical framework to understand how motility drives glassy dynamics in epithelial monolayers, showing that confluency affects the effective persistence time-scale of active force.

Modelling how curved active proteins and shear flow pattern cellular shape and motility

The paper models how curved active proteins and shear flow influence cellular shape and motility, showing cells reorient to minimize adhesion energy.

A simple cognitive model explains movement decisions during schooling in zebrafish

This paper develops a cognitive model to explain how zebrafish make movement decisions in groups, showing it can explain spatial distributions and critical bifurcations in their behavior.

Theoretical model of membrane protrusions driven by curved active proteins

The paper extends a physical model of membrane protrusions driven by curved active proteins to explore the formation of different protrusive structures like lamellipodia and filopodia.

Coiling of cellular protrusions around extracellular fibers

This study combines theory and experiments to show that cellular protrusions coil around round fibers but not elliptical ones, driven by membrane curvature and adhesion energies.

Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers

This study shows that IRSp53 couples actin filaments to the nucleus via membrane curvature during 3D cell migration on 1D fibers, affecting protrusion and contractility.

Theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

This paper presents a theoretical model explaining how curved membrane proteins and active cytoskeletal forces drive efficient phagocytosis, showing reduced adhesion strength requirements and faster engulfment.

Mitotic Outcomes in Fibrous Environments

This study investigates mitotic outcomes in fibrous environments by analyzing how cell shape, adhesion geometry, and fiber arrangement affect mitotic stability and division dynamics.

Cytoplasmic forces functionally reorganize nuclear condensates in oocytes

This study shows that cytoplasmic forces reorganize nuclear condensates in oocytes, affecting mRNA processing and meiotic divisions.

Actin-inspired feedback couples speed and persistence in a Cellular Potts Model of cell migration

This paper shows that a Cellular Potts Model of cell migration spontaneously reproduces the universal speed-persistence coupling without being designed for it.

Centering based on active diffusion in mouse oocytes is non-specific

The paper investigates nucleus centering in mouse oocytes and finds that an activity gradient induces a general centering force through biased diffusion, which is counteracted by myosin-dependent spindle off-centering.

Cell substrate patterns driven by curvature-sensitive actin polymerization: waves and podosomes.

The paper investigates how curvature-sensitive actin polymerization drives dynamic membrane protrusions and waves on the basal side of adhered cells, resembling podosomes.

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity

This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.