O. D. Weiner

The paper identifies a self-extinguishing relay wave mechanism in human neutrophils that controls swarming and recruitment levels through an NADPH-oxidase-based feedback loop.

This study identifies regulators of chemoattractant-induced neutrophil swelling and shows that cell swelling is necessary and sufficient for enhanced migration.

The paper investigates how Rac negative feedback modulates neutrophil guidance by linking local PIP3 rate-of-change to dynamic control of cell polarization.

The paper investigates how YAP activation levels and dynamics regulate pluripotency factors Oct4 and Nanog through differential thresholds and adaptive transcriptional responses.

The paper uses optogenetics and optical tweezers to show that actin-driven protrusions enable rapid, long-range membrane tension propagation, contrasting with localized force application.

This study shows WASP integrates substrate topology and cell polarity to guide neutrophil migration by selectively polymerizing actin at the leading edge.

The paper investigates how the WAVE complex self-organizes into linear structures to form lamellipodia, contrasting with N-WASP's spiky actin networks, and shows how curvature sensing enables cell shape regulation.

This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.

The paper directly tests the kinetic proofreading model of T cell activation by controlling ligand binding half-life with light, showing that lifetime, not occupancy, dominates activation.

The paper investigates size control in yeast by blocking bud initiation, showing that size regulation occurs through a timer rather than a molecular sensor.