J. P. Town

The paper investigates how Rac negative feedback modulates neutrophil guidance by linking local PIP3 rate-of-change to dynamic control of cell polarization.

The paper uses optogenetics and optical tweezers to show that actin-driven protrusions enable rapid, long-range membrane tension propagation, contrasting with localized force application.

The paper investigates how the WAVE complex self-organizes into linear structures to form lamellipodia, contrasting with N-WASP's spiky actin networks, and shows how curvature sensing enables cell shape regulation.

This study shows that neutrophils can maintain polarity and movement without branched actin networks when confined, revealing a bleb-based protrusion mechanism distinct from the conventional actin-based one.