Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability
J. Burke, X. Zhang, S. Bobbala, M. Frey, C. Fuentes, H. Haddad, S. Allen, R. Richardson, G. Ameer, E. A. Scott
This paper shows subcutaneous rapamycin delivery via nanocarriers changes its immunosuppressive mechanism, improving islet graft survival in a transplant model.
bioRxiv · Sep 3, 2020Bioengineering